Research workbench
Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor prochloraz
Analyse Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5EAG
- Type
- protein
- Length
- 528 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lanosterol 14-alpha demethylase
- UniProt
- A6ZSR0
- Ligands
- 5LU, HEM
- Pockets
- 5 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lanosterol 14-alpha demethylase | protein | 528 | 50% helix, 10% strand | A6ZSR0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 852 | 0.87 | 0.89 | 75 | 5LU, HEM |
| 2 | 303 | 0.59 | 0.77 | 40 | empty |
| 3 | 211 | 0.57 | 0.79 | 38 | empty |
| 4 | 157 | 0.49 | 0.77 | 29 | empty |
| 5 | 52 | 0.36 | 0.79 | 10 | empty |
Compared structures
- 5EAG · Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor Prochloraz · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A6ZSR0
- Elsewhere: RCSB PDB 5EAG · PDBe 5EAG · UniProt A6ZSR0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.