UniProt A6ZSR0
Lanosterol 14-alpha demethylase (A6ZSR0)
Lanosterol 14-alpha demethylase (UniProt A6ZSR0), EC 1.14.13.70: 66 experimental structures on GenesisL1, 19 ligands bound, 68 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A6ZSR0
- Protein
- Lanosterol 14-alpha demethylase
- EC
- 1.14.13.70
- Experimental structures
- 66
- Predicted models
- 0
- Ligands
- 19
- Pockets
- 68 · 15 records with a druggable one
Structures
66 records of A6ZSR0 in the MolNFT archive: 66 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WMZ | S. cerevisiae CYP51 complexed with fluconazole in the active site | x-ray diffraction | A | — | — |
| 4WMZ | S. cerevisiae CYP51 complexed with fluconazole in the active site | x-ray diffraction | A | — | — |
| 4ZDY | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with… | x-ray diffraction | A | — | — |
| 4ZDY | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) Y140F mutant complexed with… | x-ray diffraction | A | — | — |
| 4ZDZ | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with… | x-ray diffraction | A | — | — |
| 4ZDZ | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) Y140F mutant complexed with… | x-ray diffraction | A | — | — |
| 4ZE0 | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with… | x-ray diffraction | A | — | — |
| 4ZE0 | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) Y140F mutant complexed with… | x-ray diffraction | A | — | — |
| 4ZE1 | Saccharomyces cerevisiae CYP51 Y140F mutant complexed with posaconazole in the active site | x-ray diffraction | A | — | — |
| 4ZE1 | Saccharomyces cerevisiae CYP51 Y140F mutant complexed with posaconazole in the active site | x-ray diffraction | A | — | — |
| 4ZE2 | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with… | x-ray diffraction | A | HEM, 1YN | 5 (best 0.87) |
| 4ZE2 | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) Y140H mutant complexed with… | x-ray diffraction | A | — | — |
| 4ZE3 | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with… | x-ray diffraction | A | HEM, TPF | 6 (best 0.87) |
| 4ZE3 | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) Y140H mutant complexed with… | x-ray diffraction | A | — | — |
| 5EAB | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor S-tebuconazole | x-ray diffraction | A | HEM, TBX | 4 (best 0.87) |
| 5EAB | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor S-tebuconazole | x-ray diffraction | A | — | — |
| 5EAC | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor R-tebuconazole | x-ray diffraction | A | HEM, TBQ | — |
| 5EAC | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor R-tebuconazole | x-ray diffraction | A | — | — |
| 5EAD | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor S-desthio-prothioconazole | x-ray diffraction | A | HEM, 5L9 | 4 (best 0.87) |
| 5EAD | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor S-desthio-prothioconazole | x-ray diffraction | A | — | — |
| 5EAE | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor R-desthio-prothioconazole | x-ray diffraction | A | 5L8, HEM | — |
| 5EAE | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor R-desthio-prothioconazole | x-ray diffraction | A | — | — |
| 5EAF | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor Fluquinconazole | x-ray diffraction | A, B | HEM, FQC | — |
| 5EAF | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor fluquinconazole | x-ray diffraction | A, B | — | — |
| 5EAG | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor Prochloraz | x-ray diffraction | A | 5LU, HEM | — |
| 5EAG | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor prochloraz | x-ray diffraction | A | — | — |
| 5EAH | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor Difenoconazole | x-ray diffraction | A | HEM, 5LZ, 5LW, 5LX, 5LY | — |
| 5EAH | Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor difenoconazole | x-ray diffraction | A | — | — |
| 5ESE | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73R mutant complexed with… | x-ray diffraction | A | HEM, TPF | 4 (best 0.87) |
| 5ESE | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) G73R mutant complexed with… | x-ray diffraction | A | — | — |
| 5ESF | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73E mutant complexed with… | x-ray diffraction | A | HEM, TPF | — |
| 5ESF | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) G73E mutant complexed with… | x-ray diffraction | A | — | — |
| 5ESG | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73E mutant complexed with… | x-ray diffraction | A | 1YN, HEM | — |
| 5ESG | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) G73E mutant complexed with… | x-ray diffraction | A | — | — |
| 5ESH | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73W mutant in complex with… | x-ray diffraction | A | HEM, 1YN | — |
| 5ESH | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) G73W mutant in complex with… | x-ray diffraction | A | — | — |
| 5ESI | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73W mutant | x-ray diffraction | A | HEM | 5 (best 0.86) |
| 5ESI | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) G73W mutant | x-ray diffraction | A | — | — |
| 5ESJ | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G464S mutant complexed with… | x-ray diffraction | A | HEM, TPF | 4 (best 0.87) |
| 5ESJ | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) G464S mutant complexed with… | x-ray diffraction | A | — | — |
| 5ESK | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G464S mutant complexed with… | x-ray diffraction | A | 1YN, HEM | — |
| 5ESK | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) G464S mutant complexed with… | x-ray diffraction | A | — | — |
| 5ESL | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) T322I mutant complexed with… | x-ray diffraction | A | 1YN, HEM | — |
| 5ESL | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) T322I mutant complexed with… | x-ray diffraction | A | — | — |
| 5ESM | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) T322I mutant complexed with… | x-ray diffraction | A | HEM, TPF | — |
| 5ESM | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) T322I mutant complexed with… | x-ray diffraction | A | — | — |
| 5ESN | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) T322I mutant structure | x-ray diffraction | A | HEM | — |
| 5ESN | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) T322I mutant structure | x-ray diffraction | A | — | — |
| 5HS1 | Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) complexed with Voriconazole | x-ray diffraction | A | HEM, VOR | — |
| 5HS1 | Saccharomyces cerevisiae CYP51 (lanosterol 14-alpha demethylase) complexed with voriconazole | x-ray diffraction | A | — | — |
| 5UL0 | S. cerevisiae CYP51 complexed with vt-1161 | x-ray diffraction | A | HEM, VT1 | 4 (best 0.87) |
| 5UL0 | S. cerevisiae CYP51 complexed with vt-1161 | x-ray diffraction | A | HEM, VT1 | — |
| 6E8Q | S. CEREVISIAE CYP51 COMPLEXED WITH Posaconazole | x-ray diffraction | A | HEM, X2N | 5 (best 0.87) |
| 6E8Q | S. cerevisiae CYP51 complexed with posaconazole | x-ray diffraction | A | HEM, X2N | — |
| 7RY8 | S. CEREVISIAE CYP51 Y140H mutant COMPLEXED WITH Voriconazole | x-ray diffraction | A | HEM, VOR, BGC | 4 (best 0.87) |
| 7RY8 | S. cerevisiae CYP51 Y140H mutant complexed with voriconazole | x-ray diffraction | A | HEM, VOR, BGC | — |
| 7RY9 | S. CEREVISIAE CYP51 I471T mutant COMPLEXED WITH Voriconazole | x-ray diffraction | A | HEM, VOR | 4 (best 0.86) |
| 7RY9 | S. cerevisiae CYP51 I471T mutant complexed with voriconazole | x-ray diffraction | A | HEM, VOR | — |
| 7RYA | S. cerevisiae CYP51 I471T mutant complexed with itraconazole | x-ray diffraction | A | HEM, 1YN | 5 (best 0.87) |
| 7RYA | S. cerevisiae CYP51 I471T mutant complexed with itraconazole | x-ray diffraction | A | HEM, 1YN | — |
6 records more on the page itself.
Ligands
- HEM · Protoporphyrin IX containing Fe · in 36 records
- 1YN · 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one · in 7 records
- VOR · Voriconazole · in 7 records
- TPF · 2-(2,4-difluorophenyl)-1,3-di(1h-1,2,4-triazol-1-yl)propan-2-ol · in 5 records
- BGC · beta-D-glucopyranose · in 4 records
- 81H · (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(trifluoromethoxy) phenyl]pyridin-2-yl}propan-2-ol · in 2 records
- SKX · 7-(diethylamino)-N-[(2S)-2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-2-oxo-2H-1-benzopyran-3-carboxamide · in 2 records
- VT1 · (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol · in 2 records
- X2N · Posaconazole · in 2 records
- 5L8 · (2~{R})-2-(1-chloranylcyclopropyl)-1-(2-chlorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol · in 1 record
- 5L9 · (2~{S})-2-(1-chloranylcyclopropyl)-1-(2-chlorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol · in 1 record
- 5LU · Prochloraz · in 1 record
- 5LW · 1-[[(2~{S},4~{S})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole · in 1 record
- 5LX · 1-[[(2~{R},4~{S})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole · in 1 record
- 5LY · 1-[[(2~{R},4~{R})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole · in 1 record
- 5LZ · 1-[[(2~{S},4~{R})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole · in 1 record
- FQC · 3-(2,4-dichlorophenyl)-6-fluoranyl-2-(1,2,4-triazol-1-yl)quinazolin-4-one · in 1 record
- TBQ · (3~{R})-1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol · in 1 record
- TBX · (3~{S})-1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.