Research workbench
TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A, R495A) in complex with staurosporine
Analyse TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A, R495A)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5E8Y
- Type
- protein
- Length
- 298 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TGF-beta receptor type-2
- EC
- 2.7.11.30
- UniProt
- P37173
- Ligands
- STU
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TGF-beta receptor type-2 (EC 2.7.11.30) | protein | 298 | 41% helix, 20% strand | P37173 |
Ligands and binding sites
- STU · Staurosporine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 297 | 0.67 | 0.82 | 37 | STU |
| 2 | 96 | 0.60 | 0.87 | 23 | empty |
| 3 | 81 | 0.35 | 0.75 | 23 | empty |
| 4 | 78 | 0.34 | 0.75 | 22 | empty |
Compared structures
- 5E8Y · TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A,R495A) in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- P37173 · AlphaFold monomer V2.0 prediction for TGF-beta receptor type-2 (P37173) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37173
- Elsewhere: RCSB PDB 5E8Y · PDBe 5E8Y · UniProt P37173
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.