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Crystal structure of anti-tau antibody AT8 Fab

Analyse Crystal structure of anti-tau antibody AT8 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5E2T
Type: protein
Length: 425 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: AT8 light chain; AT8 heavy chain
Ligands: CA
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	AT8 light chain	protein	216	6% helix, 50% strand	—
H	AT8 heavy chain	protein	209	6% helix, 52% strand	—

Ligands and binding sites

CA · Calcium ion · metal · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	686	0.67	0.76	52	empty
2	63	0.53	0.87	21	empty
3	79	0.38	0.77	21	empty
4	50	0.29	0.76	15	empty

Interfaces

1 interface between chains.

L–H · 1634 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5E2T · Crystal structure of anti-TAU antibody AT8 FAB · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5E2T · PDBe 5E2T

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