Research workbench
Structure of trehalose-6-phosphate phosphatase from cryptococcus neoformans
Analyse Structure of trehalose-6-phosphate phosphatase from cryptococcus neoformans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5DX9
- Type
- protein
- Length
- 307 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trehalose-6-phosphate phosphatase
- EC
- 2.4.1.15
- UniProt
- Q059G6
- Ligands
- GLC, G6P, MG
- Pockets
- 2 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Trehalose-6-phosphate phosphatase (EC 2.4.1.15) | protein | 307 | 39% helix, 21% strand | Q059G6 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · chains A
- G6P · 6-O-phosphono-alpha-D-glucopyranose · sugar · chains A
- MG · Magnesium ion · metal · chains A
- BME · Beta-mercaptoethanol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 218 | 0.80 | 0.94 | 37 | GLC, G6P, MG |
| 2 | 59 | 0.32 | 0.76 | 12 | empty |
Modifications
Observed in the structure: 6 modified, 1 covalent (engineered, additive adduct).
Compared structures
- 5DX9 · Structure of trehalose-6-phosphate phosphatase from Cryptococcus neoformans · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q059G6
- Elsewhere: RCSB PDB 5DX9 · PDBe 5DX9 · UniProt Q059G6
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