Research workbench
Crystal structure of tetrahymena P45N and P19
Analyse Crystal structure of tetrahymena P45N and P19 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5DOI
- Type
- protein
- Length
- 984 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase-associated protein 19; Telomerase associated protein P45
- UniProt
- D2CVN7, Q6JXI5
- Pockets
- 16 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Telomerase-associated protein 19 | protein | 153 | 27% helix, 31% strand | D2CVN7 |
| E, F, G, H | Telomerase associated protein P45 | protein | 93 | 20% helix, 46% strand | Q6JXI5 |
Pockets
16 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.48 | 0.84 | 19 | empty |
| 2 | 59 | 0.46 | 0.83 | 21 | empty |
| 3 | 101 | 0.45 | 0.79 | 17 | empty |
| 4 | 57 | 0.43 | 0.82 | 20 | empty |
| 5 | 91 | 0.43 | 0.79 | 20 | empty |
Interfaces
14 interfaces between chains.
- C–G · 1022 Ų buried · 13 hydrogen bonds · protein-protein
- D–H · 1011 Ų buried · 14 hydrogen bonds · protein-protein
- B–F · 1010 Ų buried · 12 hydrogen bonds · protein-protein
- A–E · 1006 Ų buried · 11 hydrogen bonds · protein-protein
- E–F · 622 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5DOI · Crystal structure of Tetrahymena p45N and p19 · the same entry in another collection · chain H against H, TM-score 1.00
- Q6JXI5 · AlphaFold monomer V2.0 prediction for telomerase-associated protein of 45 kda (Q6JXI5) · a predicted model of the same protein · chain E against A, TM-score 0.98
- D2CVN7 · AlphaFold monomer V2.0 prediction for telomerase-associated protein of 19 kda (D2CVN7) · a predicted model of the same protein · chain A against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D2CVN7
- Every structure of UniProt Q6JXI5
- Elsewhere: RCSB PDB 5DOI · PDBe 5DOI · UniProt D2CVN7 · UniProt Q6JXI5
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