Research workbench
Crystal structure of the human sterol transporter ABCG5/ABCG8
Analyse Crystal structure of the human sterol transporter ABCG5/ABCG8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5DO7
- Type
- protein
- Length
- 2,297 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-binding cassette sub-family G member 5; ATP-binding cassette sub-family G member 8
- UniProt
- Q9H222, Q9H221
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 4 distinct chains · 56% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-binding cassette sub-family G member 5 | protein | 585 | 58% helix, 10% strand | Q9H222 |
| B | ATP-binding cassette sub-family G member 8 | protein | 562 | 56% helix, 9% strand | Q9H221 |
| D | ATP-binding cassette sub-family G member 8 | protein | 571 | 53% helix, 9% strand | Q9H221 |
| C | ATP-binding cassette sub-family G member 5 | protein | 579 | 58% helix, 11% strand | Q9H222 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1199 | 0.82 | 0.83 | 107 | empty |
| 2 | 415 | 0.79 | 0.87 | 47 | empty |
| 3 | 112 | 0.77 | 0.96 | 24 | empty |
| 4 | 64 | 0.77 | 0.99 | 20 | empty |
| 5 | 86 | 0.76 | 0.97 | 27 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2679 Ų buried · 31 hydrogen bonds · protein-protein
- D–C · 2678 Ų buried · 30 hydrogen bonds · protein-protein
- A–C · 1373 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 637 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 42 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5DO7 · Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8 · the same entry in another collection · chain C against C, TM-score 1.00
- Q9H222 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family G member 5 (Q9H222) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q9H221 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family G member 8 (Q9H221) · a predicted model of the same protein · chain D against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H222
- Every structure of UniProt Q9H221
- Elsewhere: RCSB PDB 5DO7 · PDBe 5DO7 · UniProt Q9H222 · UniProt Q9H221
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