Research workbench
Crystal structure of cell division cycle protein 45 (CDC45)
Analyse Crystal structure of cell division cycle protein 45 (CDC45) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5DGO
- Type
- protein
- Length
- 541 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division control protein 45 homolog
- UniProt
- O75419
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division control protein 45 homolog | protein | 541 | 51% helix, 16% strand | O75419 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 297 | 0.77 | 0.89 | 37 | EDO |
| 2 | 324 | 0.74 | 0.86 | 57 | EDO |
| 3 | 79 | 0.65 | 0.92 | 20 | empty |
| 4 | 91 | 0.39 | 0.77 | 19 | empty |
| 5 | 88 | 0.38 | 0.76 | 15 | empty |
Compared structures
- 5DGO · Crystal structure of cell division cycle protein 45 (Cdc45) · the same entry in another collection · chain A against A, TM-score 1.00
- O75419 · AlphaFold monomer V2.0 prediction for cell division control protein 45 homolog (O75419) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75419
- Elsewhere: RCSB PDB 5DGO · PDBe 5DGO · UniProt O75419
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