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Crystal structure of human CD81 large extracellular loop in complex with single chain fv fragment K13
Analyse Crystal structure of human CD81 large extracellular loop in complex with single… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5DFW
- Type
- protein
- Length
- 312 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CD81 antigen; Single chain fv fragment
- UniProt
- P60033
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CD81 antigen | protein | 90 | 66% helix, 0% strand | P60033 |
| H | Single chain fv fragment | protein | 222 | 5% helix, 47% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 204 | 0.62 | 0.82 | 38 | empty |
| 2 | 79 | 0.31 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–H · 796 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5DFW · Crystal structure of human CD81 large extracellular loop in complex with single chain fv… · the same entry in another collection · chain A against A, TM-score 1.00
- P60033 · AlphaFold monomer V2.0 prediction for CD81 antigen (P60033) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60033
- Elsewhere: RCSB PDB 5DFW · PDBe 5DFW · UniProt P60033
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