Crystal structure of the complex between human fmrp rgg motif and G- quadruplex RNA, iridium hexammine bound form.

Structure

x-ray diffraction · 3 distinct chains · 0% helix, 0% strand (DSSP).

Ligands and binding sites

• IRI · Iridium hexammine ion · ligand · 5 copies · chains A, C
• K · Potassium ion · metal · 2 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

• A–B · 688 Ų buried · 33 hydrogen bonds · protein-nucleic
• C–D · 646 Ų buried · 31 hydrogen bonds · protein-nucleic
• A–C · 195 Ų buried · 7 hydrogen bonds · nucleic-nucleic
• B–C · 46 Ų buried · 0 hydrogen bonds · protein-nucleic
• A–D · 26 Ų buried · 0 hydrogen bonds · protein-nucleic

Compared structures

• 5DE8 · Crystal structure of the complex between human FMRP RGG motif and G-quadruplex RNA… · the same entry in another collection · chain A against A, TM-score 1.00
• Q06787 · AlphaFold monomer V2.0 prediction for synaptic functional regulator FMR1 (Q06787) · a predicted model of the same protein · chain D against A, TM-score 0.26

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q06787
• Elsewhere: RCSB PDB 5DE8 · PDBe 5DE8 · UniProt Q06787