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Crystal structure analysis of hypothetical bromodomain TB427.10.7420 from trypanosoma brucei in complex with bromosporine

Analyse Crystal structure analysis of hypothetical bromodomain TB427.10.7420 from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5CZG
Type: protein
Length: 115 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical bromodomain
UniProt: D0A3H5
Ligands: BMF, NA, UNX
Pockets: 1 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hypothetical bromodomain	protein	115	57% helix, 0% strand	D0A3H5

Ligands and binding sites

BMF · Bromosporine · ligand · chains A
NA · Sodium ion · metal · 2 copies · chains A
UNX · Unknown atom or ion · ion · 10 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.53	0.82	21	BMF

Compared structures

5CZG · Crystal Structure Analysis of hypothetical bromodomain Tb427.10.7420 from Trypanosoma… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D0A3H5
Elsewhere: RCSB PDB 5CZG · PDBe 5CZG · UniProt D0A3H5

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