Research workbench
Crystal structure of the chaetomium thermophilum heterotrimeric NUP82 ntd-NUP159 tail-NUP145N apd complex
Analyse Crystal structure of the chaetomium thermophilum heterotrimeric NUP82… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CWW
- Type
- protein
- Length
- 710 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP145N; Nucleoporin NUP82; Nucleoporin NUP159
- EC
- 3.4.21.-
- UniProt
- G0SAK3, G0S4F3, G0SBS8
- Pockets
- 8 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 21% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP145N (EC 3.4.21.-) | protein | 140 | 18% helix, 29% strand | G0SAK3 |
| B | Nucleoporin NUP82 | protein | 538 | 19% helix, 30% strand | G0S4F3 |
| C | Nucleoporin NUP159 | protein | 32 | 59% helix, 6% strand | G0SBS8 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 800 | 0.79 | 0.83 | 63 | empty |
| 2 | 904 | 0.76 | 0.79 | 87 | empty |
| 3 | 466 | 0.71 | 0.81 | 52 | empty |
| 4 | 221 | 0.66 | 0.84 | 34 | empty |
| 5 | 218 | 0.53 | 0.78 | 42 | empty |
Interfaces
2 interfaces between chains.
- B–C · 1385 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1152 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 5CWW · Crystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159… · the same entry in another collection · chain A against A, TM-score 1.00
- G0S4F3 · AlphaFold monomer V2.0 prediction for nucleoporin NUP82 (G0S4F3) · a predicted model of the same protein · chain B against A, TM-score 0.99
- G0SAK3 · AlphaFold monomer V2.0 prediction for nucleoporin NUP145 (G0SAK3) · a predicted model of the same protein · chain A against A, TM-score 0.97
- G0SBS8 · AlphaFold monomer V2.0 prediction for nucleoporin NUP159 (G0SBS8) · a predicted model of the same protein · chain C against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SAK3
- Every structure of UniProt G0S4F3
- Every structure of UniProt G0SBS8
- Elsewhere: RCSB PDB 5CWW · PDBe 5CWW · UniProt G0SAK3 · UniProt G0S4F3 · UniProt G0SBS8
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