Research workbench
Crystal structure of domains bt-bccp-AC1-AC5 of yeast acetyl-CoA carboxylase
Analyse Crystal structure of domains bt-bccp-AC1-AC5 of yeast acetyl-CoA carboxylase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CSA
- Type
- protein
- Length
- 1,724 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetyl-CoA carboxylase
- EC
- 6.4.1.2, 6.3.4.14
- UniProt
- Q00955
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acetyl-CoA carboxylase (EC 6.4.1.2, 6.3.4.14) | protein | 872 | 40% helix, 23% strand | Q00955 |
| B | Acetyl-CoA carboxylase (EC 6.4.1.2, 6.3.4.14) | protein | 852 | 39% helix, 23% strand | Q00955 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.80 | 0.95 | 32 | empty |
| 2 | 671 | 0.70 | 0.78 | 67 | empty |
| 3 | 399 | 0.66 | 0.79 | 44 | empty |
| 4 | 531 | 0.65 | 0.76 | 41 | empty |
| 5 | 322 | 0.61 | 0.78 | 51 | empty |
Interfaces
1 interface between chains.
- A–B · 2119 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 5CSA · Crystal structure of domains BT-BCCP-AC1-AC5 of yeast acetyl-CoA carboxylase · the same entry in another collection · chain A against A, TM-score 1.00
- Q00955 · AlphaFold monomer V2.0 prediction for acetyl-CoA carboxylase (Q00955) · a predicted model of the same protein · chain B against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00955
- Elsewhere: RCSB PDB 5CSA · PDBe 5CSA · UniProt Q00955
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