Research workbench

MGLUR2 with glutamate analog

Analyse MGLUR2 with glutamate analog in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5CNJ
Type: protein
Length: 890 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metabotropic glutamate receptor 2
UniProt: Q14416
Ligands: 52Q, NAG
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Metabotropic glutamate receptor 2	protein	445	37% helix, 21% strand	Q14416
B	Metabotropic glutamate receptor 2	protein	445	38% helix, 20% strand	Q14416

Ligands and binding sites

52Q · (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · ligand · 2 copies · chains A, B
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1010	0.82	0.84	106	52Q
2	569	0.75	0.82	69	52Q
3	112	0.62	0.87	22	empty
4	134	0.61	0.85	26	empty
5	123	0.43	0.76	32	empty

Interfaces

1 interface between chains.

A–B · 1022 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

5CNJ · mGlur2 with glutamate analog · the same entry in another collection · chain A against A, TM-score 1.00
Q14416 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 2 (Q14416) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14416
Elsewhere: RCSB PDB 5CNJ · PDBe 5CNJ · UniProt Q14416

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.