Research workbench
Mnemiopsis leidyi ML032222A iglur lbd R703K mutant glycine complex
Analyse Mnemiopsis leidyi ML032222A iglur lbd R703K mutant glycine complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CMB
- Type
- protein
- Length
- 502 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ML032222A iglur
- Ligands
- GLY, MG, SO4
- Pockets
- 8 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ML032222A iglur | protein | 247 | 36% helix, 27% strand | — |
| B | ML032222A iglur | protein | 255 | 35% helix, 26% strand | — |
Ligands and binding sites
- GLY · Glycine · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · chains A, B
- SO4 · Sulfate ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 198 | 0.58 | 0.80 | 35 | empty |
| 2 | 103 | 0.50 | 0.81 | 21 | empty |
| 3 | 110 | 0.48 | 0.80 | 19 | empty |
| 4 | 69 | 0.32 | 0.75 | 19 | empty |
| 5 | 61 | 0.31 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1050 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 5CMB · Mnemiopsis leidyi ML032222a iGluR LBD R703K mutant glycine complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5CMB · PDBe 5CMB
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