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Crystal structure of anemone sting (nematostella vectensis) in apo 'rotated' open conformation

Analyse Crystal structure of anemone sting (nematostella vectensis) in apo 'rotated'… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5CFO
Type: protein
Length: 364 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stimulator of interferon genes
UniProt: A7SLZ2
Pockets: 3 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Stimulator of interferon genes	protein	182	41% helix, 23% strand	A7SLZ2

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1124	0.82	0.83	69	empty
2	60	0.30	0.74	15	empty
3	56	0.29	0.74	11	empty

Interfaces

1 interface between chains.

A–B · 1331 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5CFO · Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open… · the same entry in another collection · chain A against A, TM-score 1.00
A7SLZ2 · AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (A7SLZ2) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A7SLZ2
Elsewhere: RCSB PDB 5CFO · PDBe 5CFO · UniProt A7SLZ2

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