Research workbench
Structure of the human glucose transporter GLUT3 / SLC2A3
Analyse Structure of the human glucose transporter GLUT3 / SLC2A3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5C65
- Type
- protein
- Length
- 909 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Solute carrier family 2, facilitated glucose transporter member 3
- UniProt
- P11169
- Ligands
- 37X, Y01
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier family 2, facilitated glucose transporter member 3 | protein | 457 | 79% helix, 0% strand | P11169 |
| B | Solute carrier family 2, facilitated glucose transporter member 3 | protein | 452 | 81% helix, 0% strand | P11169 |
Ligands and binding sites
- 37X · Octyl Glucose Neopentyl Glycol · ligand · 9 copies · chains A, B
- Y01 · Cholesterol hemisuccinate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 737 | 0.78 | 0.82 | 51 | empty |
| 2 | 776 | 0.77 | 0.81 | 55 | empty |
| 3 | 229 | 0.63 | 0.81 | 26 | empty |
| 4 | 217 | 0.49 | 0.75 | 27 | empty |
| 5 | 93 | 0.38 | 0.76 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 520 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5C65 · Structure of the human glucose transporter GLUT3 / SLC2A3 · the same entry in another collection · chain A against A, TM-score 1.00
- P11169 · AlphaFold monomer V2.0 prediction for solute carrier family 2, facilitated glucose… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11169
- Elsewhere: RCSB PDB 5C65 · PDBe 5C65 · UniProt P11169
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