Research workbench
Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the broadly neutralizing antibody CR6261
Analyse Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5C0S
- Type
- protein
- Length
- 675 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin, envelope glycoprotein, fibritin fusion protein; CR6261 antibody heavy…
- UniProt
- Q6WG00, P04578, D9IEJ2
- Pockets
- 9 · best druggability 0.51
Structure
x-ray diffraction · 3 distinct chains · 22% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemagglutinin, envelope glycoprotein, fibritin fusion protein | protein | 242 | 53% helix, 17% strand | Q6WG00, P04578, D9IEJ2 |
| H | CR6261 antibody heavy chain | protein | 221 | 4% helix, 49% strand | — |
| L | CR6261 antibody light chain | protein | 212 | 6% helix, 50% strand | — |
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 306 | 0.51 | 0.73 | 39 | empty |
| 2 | 131 | 0.45 | 0.77 | 27 | empty |
| 3 | 100 | 0.41 | 0.77 | 21 | empty |
| 4 | 116 | 0.40 | 0.76 | 14 | empty |
| 5 | 102 | 0.39 | 0.75 | 19 | empty |
Interfaces
2 interfaces between chains.
- H–L · 1790 Ų buried · 16 hydrogen bonds · protein-protein
- A–H · 718 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 5C0S · Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6WG00
- Every structure of UniProt P04578
- Every structure of UniProt D9IEJ2
- Elsewhere: RCSB PDB 5C0S · PDBe 5C0S · UniProt Q6WG00 · UniProt P04578 · UniProt D9IEJ2
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