UniProt P04578
Transmembrane protein gp41 (P04578)
Transmembrane protein gp41 (UniProt P04578): 62 experimental structures on GenesisL1, 3 ligands bound, 7 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P04578
- Protein
- Transmembrane protein gp41
- Experimental structures
- 62
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 7 · 1 record with a druggable one
Structures
62 records of P04578 in the MolNFT archive: 62 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AIK | HIV GP41 core structure | x-ray diffraction | N, C | — | — |
| 1AIK | HIV GP41 core structure | x-ray diffraction | N, C | — | — |
| 1DF4 | Interactions between HIV-1 GP41 core and detergents and their implications for membrane fusion | x-ray diffraction | A | — | — |
| 1DF4 | Interactions between HIV-1 GP41 core and detergents and their implications for membrane fusion | x-ray diffraction | A | — | — |
| 1DF5 | Interactions between HIV-1 GP41 core and detergents and their implications for membrane fusion | x-ray diffraction | A | — | — |
| 1DF5 | Interactions between HIV-1 GP41 core and detergents and their implications for membrane fusion | x-ray diffraction | A | — | — |
| 1DLB | Helical interactions in the HIV-1 GP41 core reveals structural basis for the inhibitory activity of… | x-ray diffraction | A | — | — |
| 1DLB | Helical interactions in the HIV-1 GP41 core reveals structural basis for the inhibitory activity of… | x-ray diffraction | A | — | — |
| 1G9M | HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | G | — | — |
| 1G9M | HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | G | — | — |
| 1GC1 | HIV-1 GP120 core complexed with CD4 and a neutralizing human antibody | x-ray diffraction | G | — | — |
| 1GC1 | HIV-1 GP120 core complexed with CD4 and a neutralizing human antibody | x-ray diffraction | G | — | — |
| 1GZL | Crystal structure of C14linkmid/IQN17: a cross-linked inhibitor of HIV-1 entry bound to the gp41… | x-ray diffraction | A, B, C, D | — | — |
| 1GZL | Crystal structure of C14LINKMID/IQN17: a cross-linked inhibitor of HIV-1 entry bound to the GP41… | x-ray diffraction | A, B, C, D | — | — |
| 1K33 | Crystal structure analysis of the gp41 core mutant | x-ray diffraction | A | — | — |
| 1K33 | Crystal structure analysis of the GP41 core mutant | x-ray diffraction | A | — | — |
| 1K34 | Crystal structure analysis of gp41 core mutant | x-ray diffraction | A | — | — |
| 1K34 | Crystal structure analysis of GP41 core mutant | x-ray diffraction | A | — | — |
| 1MZI | Solution ensemble structures of HIV-1 gp41 2F5 mAb epitope | solution nmr | A | — | — |
| 1MZI | Solution ensemble structures of HIV-1 GP41 2F5 mab epitope | solution nmr | A | — | — |
| 1RZJ | HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | G | — | — |
| 1RZJ | HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing antibody 17B | x-ray diffraction | G | — | — |
| 2CMR | Crystal structure of the HIV-1 neutralizing antibody D5 Fab bound to the gp41 inner-core mimetic… | x-ray diffraction | A | — | — |
| 2CMR | Crystal structure of the HIV-1 neutralizing antibody D5 Fab bound to the GP41 inner-core mimetic… | x-ray diffraction | A | — | — |
| 2ME1 | HIV-1 gp41 clade B double alanine mutant Membrane Proximal External Region peptide in DPC micelle | solution nmr | A | — | — |
| 2ME1 | HIV-1 GP41 clade B double alanine mutant membrane proximal external region peptide in dpc micelle | solution nmr | A | — | — |
| 2MG1 | NMR assignment and structure of a peptide derived from the trans-membrane region of HIV-1 gp41 in… | solution nmr | A | — | — |
| 2MG1 | NMR assignment and structure of a peptide derived from the trans- membrane region of HIV-1 GP41 in… | solution nmr | A | — | — |
| 2NY7 | HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody… | x-ray diffraction | G | — | — |
| 2NY7 | HIV-1 GP120 envelope glycoprotein complexed with the broadly neutralizing CD4-binding-site antibody… | x-ray diffraction | G | — | — |
| 2PV6 | HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle | solution nmr | A | — | — |
| 2PV6 | HIV-1 GP41 membrane proximal ectodomain region peptide in dpc micelle | solution nmr | A | — | — |
| 2X7R | Crystal structure of a late fusion intermediate of HIV-1 gp41 | x-ray diffraction | A, B, C, D, E, N | — | — |
| 2X7R | Crystal structure of a late fusion intermediate of HIV-1 GP41 | x-ray diffraction | A, B, C, D, E, N | — | — |
| 2XRA | crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix | x-ray diffraction | A | — | — |
| 2XRA | Crystal structure of the HK20 Fab in complex with a GP41 mimetic 5- helix | x-ray diffraction | A | — | — |
| 2ZZO | Crystal structure of the complex between GP41 fragment N36 and fusion inhibitor C34/S138A | x-ray diffraction | N, C | — | — |
| 2ZZO | Crystal structure of the complex between GP41 fragment N36 and fusion inhibitor C34/S138A | x-ray diffraction | C | — | — |
| 3DNL | Molecular structure for the HIV-1 gp120 trimer in the b12-bound state | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 3DNL | Molecular structure for the HIV-1 GP120 trimer in the B12-bound state | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 3DNN | Molecular structure for the HIV-1 gp120 trimer in the unliganded state | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 3DNN | Molecular structure for the HIV-1 GP120 trimer in the unliganded state | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 3DNO | Molecular structure for the HIV-1 gp120 trimer in the CD4-bound state | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 3DNO | Molecular structure for the HIV-1 GP120 trimer in the CD4-bound state | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 3J70 | Model of gp120, including variable regions, in complex with CD4 and 17b | electron microscopy | D, P, U | — | — |
| 3J70 | Model of GP120, including variable regions, in complex with CD4 and 17B | electron microscopy | D, P, U | — | — |
| 3TYG | Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a… | x-ray diffraction | A | — | — |
| 3TYG | Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a… | x-ray diffraction | A | — | — |
| 5C0R | Crystal structure of a generation 3 influenza hemagglutinin stabilized stem complexed with the… | x-ray diffraction | A | — | — |
| 5C0S | Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the… | x-ray diffraction | A | — | 4 (best 0.41) |
| 5C0S | Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the… | x-ray diffraction | A | — | — |
| 5HM1 | Llama VHH 2E7 in complex with gp41 | x-ray diffraction | D, E, F | — | — |
| 5HM1 | Llama vhh 2E7 in complex with GP41 | x-ray diffraction | D, E, F | — | — |
| 5KA5 | HIV-1 GP41 variant V549E resistance mutation | x-ray diffraction | A | — | — |
| 5KA6 | HIV-1 gp41 variant Q552R and L555M resistance mutations | x-ray diffraction | A, B, C | — | 1 (best 0.69) |
| 5KA6 | HIV-1 GP41 variant Q552R and L555M resistance mutations | x-ray diffraction | A, B, C | — | — |
| 6DLN | Oligomeric structure of the HIV GP41 mper-tmd in phospholipid bilayers | solid-state nmr | A, B, C | — | — |
| 6PSA | PIE12 D-peptide against HIV entry (in complex with IQN17 Q577R resistance mutant) | x-ray diffraction | A | CL | — |
| 6PSA | PIE12 D-peptide against HIV entry (in complex with IQN17 Q577R resistance mutant) | x-ray diffraction | A | ACE, NH2, CL | — |
| 8TQ7 | Crystal structure of Fab.34.2.12 in complex with MHC-I (H2-Dd) | x-ray diffraction | E, P | — | — |
2 records more on the page itself.
Ligands
Experiment against prediction
- 6PSA chain A against the predicted model P03069: TM-score 0.86, RMSD 0.87 Å
- 6PSA chain A against the predicted model P03069: TM-score 0.86, RMSD 0.87 Å
- 1GZL chain A against the predicted model P03069: TM-score 0.82, RMSD 1.06 Å
- 1GZL chain A against the predicted model P03069: TM-score 0.82, RMSD 1.06 Å
- 1GZL chain B against the predicted model P03069: TM-score 0.80, RMSD 1.12 Å
- 1GZL chain B against the predicted model P03069: TM-score 0.80, RMSD 1.12 Å
Elsewhere
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