Research workbench
Structural basis for the recognition of a nucleoporin fg- repeat by the NTF2-like domain of tap-P15 mRNA export factor
Analyse Structural basis for the recognition of a nucleoporin fg- repeat by the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JN5
- Type
- protein
- Length
- 324 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- P15; Tap; Fg-repeat
- UniProt
- Q9UKK6, Q9UBU9
- Pockets
- 5 · best druggability 0.55
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | P15 | protein | 136 | 29% helix, 41% strand | Q9UKK6 |
| B | Tap | protein | 182 | 31% helix, 32% strand | Q9UBU9 |
| C | Fg-repeat | protein | 6 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 176 | 0.55 | 0.80 | 22 | empty |
| 2 | 142 | 0.44 | 0.76 | 31 | empty |
| 3 | 97 | 0.38 | 0.76 | 25 | empty |
| 4 | 59 | 0.33 | 0.77 | 14 | empty |
| 5 | 50 | 0.30 | 0.76 | 11 | empty |
Interfaces
2 interfaces between chains.
- A–B · 2015 Ų buried · 30 hydrogen bonds · protein-protein
- B–C · 251 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1JN5 · Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UKK6 · AlphaFold monomer V2.0 prediction for NTF2-related export protein 1 (Q9UKK6) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9UBU9 · AlphaFold monomer V2.0 prediction for nuclear RNA export factor 1 (Q9UBU9) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UKK6
- Every structure of UniProt Q9UBU9
- Elsewhere: RCSB PDB 1JN5 · PDBe 1JN5 · UniProt Q9UKK6 · UniProt Q9UBU9
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