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Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with NADP, hepes and L(+)-tartaric acid

Analyse Probable 2-hydroxyacid dehydrogenase from rhizobium etli cfn 42 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5BQF
Type: protein
Length: 317 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NADP-dependent 2-hydroxyacid dehydrogenase
UniProt: Q2KDT2
Ligands: NAP, NA, CL
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NADP-dependent 2-hydroxyacid dehydrogenase	protein	317	34% helix, 16% strand	Q2KDT2

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
NA · Sodium ion · metal · chains A
CL · Chloride ion · ion · chains A
EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A
PEG · Di(hydroxyethyl)ether · additive · chains A
TLA · L(+)-tartaric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	656	0.77	0.83	67	EPE, NAP, TLA
2	97	0.41	0.77	20	empty

Analyse

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Every structure of UniProt Q2KDT2
Elsewhere: RCSB PDB 5BQF · PDBe 5BQF · UniProt Q2KDT2

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