Research workbench
Human insulin with intra-chain chemical crosslink between modified B27 and B29
Analyse Human insulin with intra-chain chemical crosslink between modified B27 and B29 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5BPO
- Type
- protein
- Length
- 99 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin
- UniProt
- P01308
Structure
x-ray diffraction · 3 distinct chains · 51% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin | protein | 21 | 57% helix, 5% strand | P01308 |
| B | Insulin | protein | 29 | 48% helix, 3% strand | P01308 |
| D | Insulin | protein | 28 | 50% helix, 4% strand | P01308 |
Interfaces
6 interfaces between chains.
- C–D · 605 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 543 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 292 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 247 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 160 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 4 modified (disulfide, nonstandard).
Compared structures
- 5BPO · Human insulin with intra-chain chemical crosslink between modified B27 and B29 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 5BPO · PDBe 5BPO · UniProt P01308
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