Research workbench
Structure model of SAP1-DNA complex
Analyse Structure model of SAP1-DNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5B7J
- Type
- protein + DNA
- Length
- 135 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Switch-activating protein 1; DNA (5'-D(*CP*AP*AP*AP*AP*CP*AP*AP*TP*AP*TP*T)-3'); DNA…
- UniProt
- P40847
- Pockets
- 3 · best druggability 0.56
Structure
solution nmr · 3 distinct chains · 62% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Switch-activating protein 1 | protein | 111 | 62% helix, 0% strand | P40847 |
| B | DNA (5'-D(*CP*AP*AP*AP*AP*CP*AP*AP*TP*AP*TP*T)-3') | dna | 12 | — | — |
| C | DNA (5'-D(*AP*AP*TP*AP*TP*TP*GP*TP*TP*TP*TP*G)-3') | dna | 12 | — | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.56 | 0.79 | 27 | empty |
| 2 | 162 | 0.51 | 0.79 | 23 | empty |
| 3 | 50 | 0.30 | 0.77 | 10 | empty |
Interfaces
3 interfaces between chains.
- A–B · 630 Ų buried · 9 hydrogen bonds · protein-nucleic
- A–C · 587 Ų buried · 11 hydrogen bonds · protein-nucleic
- B–C · 557 Ų buried · 52 hydrogen bonds · nucleic-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40847
- Elsewhere: RCSB PDB 5B7J · PDBe 5B7J · UniProt P40847
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