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Crystal structure of GSDMA3

Analyse Crystal structure of GSDMA3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5B5R
Type: protein
Length: 409 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gasdermin-A3
UniProt: Q5Y4Y6
Pockets: 8 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gasdermin-A3	protein	409	43% helix, 21% strand	Q5Y4Y6

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	351	0.65	0.80	45	empty
2	306	0.61	0.79	38	empty
3	263	0.51	0.75	38	empty
4	136	0.37	0.73	23	empty
5	74	0.33	0.75	12	empty

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

5B5R · Crystal structure of GSDMA3 · the same entry in another collection · chain A against A, TM-score 1.00
Q5Y4Y6 · AlphaFold monomer V2.0 prediction for gasdermin-A3 (Q5Y4Y6) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5Y4Y6
Elsewhere: RCSB PDB 5B5R · PDBe 5B5R · UniProt Q5Y4Y6

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