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Crystal structure of human ptprz D1 domain

Analyse Crystal structure of human ptprz D1 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5AWX
Type: protein
Length: 283 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase zeta
EC: 3.1.3.48
UniProt: P23471
Ligands: BR
Pockets: 3 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase zeta (EC 3.1.3.48)	protein	283	35% helix, 24% strand	P23471

Ligands and binding sites

BR · Bromide ion · ion · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.44	0.76	22	BR
2	79	0.38	0.77	14	empty
3	83	0.34	0.75	23	BR

Compared structures

5AWX · Crystal structure of Human PTPRZ D1 domain · the same entry in another collection · chain A against A, TM-score 1.00
P23471 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase zeta… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23471
Elsewhere: RCSB PDB 5AWX · PDBe 5AWX · UniProt P23471

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