MolNFT v1 · #319887 · protein
AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase zeta (P23471)
P23471: “AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase zeta (P23471)”. 20 pockets (best druggability 0.75). MolNFT v1 #319887 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P23471
- Type
- protein
- Length
- 2,315 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x16CCa6E3e9FB6F3BA58AD90F1CA9Ed23Cf6fc7d2
- Molecule
- Receptor-type tyrosine-protein phosphatase zeta
- UniProt
- P23471
- Pockets
- 20 · best druggability 0.75
Structure
1 distinct chain · 14% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase zeta | protein | 2315 | 14% helix, 12% strand | P23471 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.75 | 0.98 | 20 | empty |
| 2 | 1094 | 0.74 | 0.77 | 77 | empty |
| 3 | 303 | 0.63 | 0.80 | 38 | empty |
| 4 | 407 | 0.62 | 0.77 | 30 | empty |
| 5 | 309 | 0.56 | 0.76 | 46 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 5AWX · Crystal structure of Human PTPRZ D1 domain · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 5AWX · Crystal structure of human ptprz D1 domain · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 5H08 · Human ptprz D1 domain complexed with NAZ2329 · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 5H08 · Human PTPRZ D1 domain complexed with NAZ2329 · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 3JXF · Ca-like domain of human ptprz · an experimental structure of the same protein · chain A against B, TM-score 0.12
- 3JXF · CA-like domain of human PTPRZ · an experimental structure of the same protein · chain A against B, TM-score 0.12
- 3S97 · Ptprz CNTN1 complex · an experimental structure of the same protein · chain A against A, TM-score 0.11
- 3S97 · PTPRZ CNTN1 complex · an experimental structure of the same protein · chain A against A, TM-score 0.11
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23471
- Elsewhere: UniProt P23471 · AlphaFold DB P23471
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