MolNFT v1 · #68492 · protein
Ca-like domain of human ptprz
3JXF · Receptor-type tyrosine-protein phosphatase zeta: “Ca-like domain of human ptprz”. X-ray diffraction, 3 pockets (best druggability 0.80). MolNFT v1 #68492 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3JXF
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase zeta
- EC
- 3.1.3.48
- UniProt
- P23471
- Pockets
- 3 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase zeta (EC 3.1.3.48) | protein | 268 | 17% helix, 33% strand | P23471 |
| B | Receptor-type tyrosine-protein phosphatase zeta (EC 3.1.3.48) | protein | 271 | 16% helix, 33% strand | P23471 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1116 | 0.80 | 0.81 | 89 | empty |
| 2 | 296 | 0.61 | 0.79 | 24 | empty |
| 3 | 101 | 0.44 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 398 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23471
- Elsewhere: RCSB PDB 3JXF · PDBe 3JXF · UniProt P23471
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