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Crystal structure of the conserved N-terminal domain of PEX14 from trypanosoma brucei

Analyse Crystal structure of the conserved N-terminal domain of PEX14 from trypanosoma… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5AON
Type: protein
Length: 244 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxin 14
UniProt: Q8IEW2
Ligands: SO4
Pockets: 3 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Peroxin 14	protein	49	76% helix, 0% strand	Q8IEW2
E	Peroxin 14	protein	48	79% helix, 0% strand	Q8IEW2

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, D, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.55	0.79	27	SO4
2	54	0.30	0.75	15	empty
3	51	0.29	0.75	15	empty

Interfaces

6 interfaces between chains.

B–C · 578 Å² buried · 6 hydrogen bonds · protein-protein
A–D · 540 Å² buried · 5 hydrogen bonds · protein-protein
A–E · 508 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 507 Å² buried · 6 hydrogen bonds · protein-protein
B–D · 31 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5AON · Crystal structure of the conserved N-terminal domain of Pex14 from Trypanosoma brucei · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt Q8IEW2
Elsewhere: RCSB PDB 5AON · PDBe 5AON · UniProt Q8IEW2

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