Research workbench
Crystal structure of RPC62 - RPC32 beta
Analyse Crystal structure of RPC62 - RPC32 beta in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5AFQ
- Type
- protein
- Length
- 959 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-directed RNA polymerase III subunit RPC3; RPC32 beta (RPC7L)
- UniProt
- Q9BUI4
- Pockets
- 16 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 64% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase III subunit RPC3 | protein | 443 | 65% helix, 6% strand | Q9BUI4 |
| B | DNA-directed RNA polymerase III subunit RPC3 | protein | 444 | 65% helix, 7% strand | Q9BUI4 |
| D | RPC32 beta (RPC7L) | protein | 53 | 28% helix, 0% strand | — |
| E | RPC32 beta (RPC7L) | protein | 19 | 84% helix, 0% strand | — |
Pockets
16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.79 | 0.81 | 125 | empty |
| 2 | 416 | 0.78 | 0.86 | 54 | empty |
| 3 | 115 | 0.66 | 0.89 | 25 | empty |
| 4 | 93 | 0.65 | 0.90 | 23 | empty |
| 5 | 401 | 0.65 | 0.78 | 36 | empty |
Interfaces
3 interfaces between chains.
- A–D · 1382 Ų buried · 5 hydrogen bonds · protein-protein
- B–E · 407 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 227 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BUI4
- Elsewhere: RCSB PDB 5AFQ · PDBe 5AFQ · UniProt Q9BUI4
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