Research workbench
Crystal structure of salmonella enterica hisa D7N D176A with profar
Analyse Crystal structure of salmonella enterica hisa D7N D176A with profar in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5A5W
- Type
- protein
- Length
- 245 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1-(5-phosphoribosyl)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENE amino] imidazole-4-carboxamide…
- EC
- 5.3.1.16
- UniProt
- P10372
- Ligands
- GUO
- Pockets
- 1 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1-(5-phosphoribosyl)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENE amino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) | protein | 245 | 40% helix, 25% strand | P10372 |
Ligands and binding sites
- GUO · [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S, 5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 297 | 0.84 | 0.95 | 47 | GUO |
Compared structures
- 5A5W · Crystal structure of Salmonella enterica HisA D7N D176A with ProFAR · the same entry in another collection · chain A against A, TM-score 1.00
- P10372 · AlphaFold monomer V2.0 prediction for 1-(5-phosphoribosyl)-5-[(5-PHOSPHORIBOSYLAMINO)METHY… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10372
- Elsewhere: RCSB PDB 5A5W · PDBe 5A5W · UniProt P10372
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