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Crystal structure of human autocrine motility factor
Analyse Crystal structure of human autocrine motility factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JIQ
- Type
- protein
- Length
- 2,228 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Autocrine motility factor
- EC
- 5.3.1.9
- UniProt
- P06744
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Autocrine motility factor (EC 5.3.1.9) | protein | 557 | 55% helix, 12% strand | P06744 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1022 | 0.78 | 0.80 | 65 | empty |
| 2 | 963 | 0.78 | 0.80 | 64 | empty |
| 3 | 505 | 0.73 | 0.82 | 52 | empty |
| 4 | 477 | 0.72 | 0.82 | 53 | empty |
| 5 | 501 | 0.71 | 0.81 | 47 | empty |
Interfaces
3 interfaces between chains.
- C–D · 6703 Ų buried · 97 hydrogen bonds · protein-protein
- A–B · 6663 Ų buried · 93 hydrogen bonds · protein-protein
- A–C · 59 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06744
- Elsewhere: RCSB PDB 1JIQ · PDBe 1JIQ · UniProt P06744
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