Research workbench
Human gar transformylase in complex with gar and (S)-2-(8-(2-amino-4- oxo-4,7-dihydro-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO) pentanedioic acid (AGF147)
Analyse Human gar transformylase in complex with gar and (S)-2-(8-(2-amino-4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZZ0
- Type
- protein
- Length
- 200 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trifunctional purine biosynthetic protein adenosine-3
- EC
- 2.1.2.2
- UniProt
- P22102
- Ligands
- GAR, 3YE
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Trifunctional purine biosynthetic protein adenosine-3 (EC 2.1.2.2) | protein | 200 | 37% helix, 24% strand | P22102 |
Ligands and binding sites
- GAR · Glycinamide ribonucleotide · ligand · chains A
- 3YE · (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 287 | 0.66 | 0.82 | 37 | GAR, 3YE |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22102
- Elsewhere: RCSB PDB 4ZZ0 · PDBe 4ZZ0 · UniProt P22102
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