UniProt P22102
Trifunctional purine biosynthetic protein adenosine-3 (P22102)
Trifunctional purine biosynthetic protein adenosine-3 (UniProt P22102), EC 2.1.2.2: 61 experimental structures on GenesisL1, 7 ligands bound, 1 pocket. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P22102
- Protein
- Trifunctional purine biosynthetic protein adenosine-3
- EC
- 2.1.2.2
- Experimental structures
- 61
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 1 · 1 record with a druggable one
Structures
61 records of P22102 in the MolNFT archive: 61 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MEJ | Human Glycinamide Ribonucleotide Transformylase domain at pH 8.5 | x-ray diffraction | B, A, C | — | — |
| 1MEJ | Human glycinamide ribonucleotide transformylase domain at pH 8.5 | x-ray diffraction | B, A, C | — | — |
| 1MEN | complex structure of human GAR Tfase and substrate beta-GAR | x-ray diffraction | A, B, C | — | — |
| 1MEN | Complex structure of human gar tfase and substrate beta-gar | x-ray diffraction | A, B, C | — | — |
| 1MEO | human glycinamide ribonucleotide Transformylase at pH 4.2 | x-ray diffraction | A | — | — |
| 1MEO | Human glycinamide ribonucleotide transformylase at pH 4.2 | x-ray diffraction | A | — | — |
| 1NJS | human GAR Tfase in complex with hydrolyzed form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-t… | x-ray diffraction | A, B | — | — |
| 1NJS | Human gar tfase in complex with hydrolyzed form of 10… | x-ray diffraction | A, B | — | — |
| 1RBM | Human GAR Tfase complex structure with polyglutamated… | x-ray diffraction | A, B | — | — |
| 1RBM | Human gar tfase complex structure with polyglutamated 10… | x-ray diffraction | A, B | — | — |
| 1RBQ | Human GAR Tfase complex structure with 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofo… | x-ray diffraction | A, B, C, D | — | — |
| 1RBQ | Human gar tfase complex structure with 10-(trifluoroacetyl)… | x-ray diffraction | A, B, C, D | — | — |
| 1RBY | Human GAR Tfase complex structure with 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofo… | x-ray diffraction | A, B, C, D | — | — |
| 1RBY | Human gar tfase complex structure with 10-(trifluoroacetyl)… | x-ray diffraction | A, B, C, D | — | — |
| 1RBZ | Human GAR Tfase complex structure with polyglutamated… | x-ray diffraction | A, B | — | — |
| 1RBZ | Human gar tfase complex structure with polyglutamated 10… | x-ray diffraction | A, B | — | — |
| 1RC0 | Human GAR Tfase complex structure with polyglutamated… | x-ray diffraction | A, B | — | — |
| 1RC0 | Human gar tfase complex structure with polyglutamated 10… | x-ray diffraction | A, B | — | — |
| 1RC1 | Human GAR Tfase complex structure with polyglutamated… | x-ray diffraction | A, B | — | — |
| 1RC1 | Human gar tfase complex structure with polyglutamated 10… | x-ray diffraction | A, B | — | — |
| 1ZLX | The apo structure of human glycinamide ribonucleotide transformylase | x-ray diffraction | A | — | — |
| 1ZLX | The apo structure of human glycinamide ribonucleotide transformylase | x-ray diffraction | A | — | — |
| 1ZLY | The structure of human glycinamide ribonucleotide transformylase in complex with… | x-ray diffraction | A | — | — |
| 1ZLY | The structure of human glycinamide ribonucleotide transformylase in complex with… | x-ray diffraction | A | — | — |
| 2QK4 | Human glycinamide ribonucleotide synthetase | x-ray diffraction | A, B | — | — |
| 2QK4 | Human glycinamide ribonucleotide synthetase | x-ray diffraction | A, B | — | — |
| 2V9Y | Human aminoimidazole ribonucleotide synthetase | x-ray diffraction | A, B | — | — |
| 2V9Y | Human aminoimidazole ribonucleotide synthetase | x-ray diffraction | A, B | — | — |
| 4EW1 | High resolution structure of human glycinamide ribonucleotide transformylase in apo form. | x-ray diffraction | A | — | — |
| 4EW1 | High resolution structure of human glycinamide ribonucleotide transformylase in apo form. | x-ray diffraction | A | — | — |
| 4EW2 | The structure of human glycinamide ribonucleotide transformylase in complex with… | x-ray diffraction | A | — | — |
| 4EW2 | The structure of human glycinamide ribonucleotide transformylase in complex with… | x-ray diffraction | A | — | — |
| 4EW3 | The structure of human glycinamide ribonucleotide transformylase in complex with… | x-ray diffraction | A | — | — |
| 4EW3 | The structure of human glycinamide ribonucleotide transformylase in complex with… | x-ray diffraction | A | — | — |
| 4ZYT | Human GAR transformylase in complex with GAR and N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d… | x-ray diffraction | A | GAR, 3Y9 | 1 (best 0.66) |
| 4ZYT | Human gar transformylase in complex with gar and N-{4-[4-(2-amino-4… | x-ray diffraction | A | — | — |
| 4ZYU | Human GAR transformylase in complex with GAR and N-{4-[4-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyri… | x-ray diffraction | A | — | — |
| 4ZYU | Human gar transformylase in complex with gar and N-{4-[4-(2-amino-4… | x-ray diffraction | A | — | — |
| 4ZYV | Human GAR transformylase in complex with GAR and N-({5-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]… | x-ray diffraction | A | — | — |
| 4ZYV | Human gar transformylase in complex with gar and N-({5-[(2-amino-4… | x-ray diffraction | A | — | — |
| 4ZYW | Human GAR transformylase in complex with GAR and N-({5-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]… | x-ray diffraction | A | — | — |
| 4ZYW | Human gar transformylase in complex with gar and N-({5-[(2-amino-4… | x-ray diffraction | A | — | — |
| 4ZYX | Human GAR transformylase in complex with GAR and (S)-2-({4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[… | x-ray diffraction | A | — | — |
| 4ZYX | Human gar transformylase in complex with gar and (S)-2-({4-[4-(2… | x-ray diffraction | A | — | — |
| 4ZYY | Human GAR transformylase in complex with GAR and (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[… | x-ray diffraction | A | — | — |
| 4ZYY | Human gar transformylase in complex with gar and (S)-2-({5-[4-(2… | x-ray diffraction | A | — | — |
| 4ZYZ | Human GAR transformylase in complex with GAR and (S)-2-(7-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3… | x-ray diffraction | A | — | — |
| 4ZYZ | Human gar transformylase in complex with gar and (S)-2-(7-(2-amino-4… | x-ray diffraction | A | — | — |
| 4ZZ0 | Human gar transformylase in complex with gar and (S)-2-(8-(2-amino-4… | x-ray diffraction | A | — | — |
| 4ZZ1 | Human gar transformylase in complex with gar and (S)-2-({4-[3-(2-amino-4-oxo-4,7-dihydro-3H-PYRROLO[… | x-ray diffraction | A | — | — |
| 4ZZ1 | Human gar transformylase in complex with gar and (S)-2-({4-[3-(2… | x-ray diffraction | A | — | — |
| 4ZZ2 | Human gar transformylase in complex with gar and (S)-2-({5-[3-(2-amino-4-oxo-4,7-dihydro-3H-PYRROLO[… | x-ray diffraction | A | — | — |
| 4ZZ2 | Human gar transformylase in complex with gar and (S)-2-({5-[3-(2… | x-ray diffraction | A | — | — |
| 4ZZ3 | Human GAR transformylase in complex with GAR and pemetrexed | x-ray diffraction | A | — | — |
| 4ZZ3 | Human gar transformylase in complex with gar and pemetrexed | x-ray diffraction | A | — | — |
| 5J9F | Human gar transformylase in complex with gar and (4-{[2-(2-amino-4… | x-ray diffraction | A | — | — |
| 7JG0 | Human gar transformylase in complex with gar substrate and AGF102 inhibitor | x-ray diffraction | A | GAR, V97 | — |
| 7JG3 | Human gar transformylase in complex with gar substrate and AGF103 inhibitor | x-ray diffraction | A | GAR, V9A, NA | — |
| 7JG4 | Human gar transformylase in complex with gar substrate and AGF131 inhibitor | x-ray diffraction | A | GAR, V9V, NA | — |
| 8FJX | Human GAR transformylase in complex with GAR substrate and AGF320 inhibitor | x-ray diffraction | A | Y7L, GAR | — |
1 record more on the page itself.
Ligands
- GAR · Glycinamide ribonucleotide · in 5 records
- NA · Sodium ion · in 2 records
- 3Y9 · N-{4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid · in 1 record
- V97 · N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl}-L-glutamic acid · in 1 record
- V9A · N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]furan-2-carbonyl}-L-glutamic acid · in 1 record
- V9V · N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3, 5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid · in 1 record
- Y7L · N-{5-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl}-L-glutamic acid · in 1 record
Elsewhere
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