Human gar transformylase in complex with gar and N-({5-[(2-amino-4- oxo-4,7-dihydro-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)PROPYL]THIOPHEN-2- YL}CARBONYL)-L-glutamic acid (AGF94)

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 24% strand (DSSP).

Ligands and binding sites

• GAR · Glycinamide ribonucleotide · ligand · chains A
• G94 · N-({5-[3-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophen-2-yl}carbonyl)-L-glutamic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 4ZYW · Human GAR transformylase in complex with GAR and… · the same entry in another collection · chain A against A, TM-score 1.00
• P22102 · AlphaFold monomer V2.0 prediction for trifunctional purine biosynthetic protein… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P22102
• Elsewhere: RCSB PDB 4ZYW · PDBe 4ZYW · UniProt P22102