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Carbohydrate binding domain from streptococcus pneumoniae nana sialidase

Analyse Carbohydrate binding domain from streptococcus pneumoniae nana sialidase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ZXK
Type: protein
Length: 376 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sialidase a
EC: 3.2.1.18
UniProt: P62575
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Sialidase a (EC 3.2.1.18)	protein	188	11% helix, 46% strand	P62575

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	117	0.46	0.78	20	empty
2	95	0.37	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 304 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4ZXK · Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase · the same entry in another collection · chain A against A, TM-score 1.00
P62575 · AlphaFold monomer V2.0 prediction for sialidase a (P62575) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62575
Elsewhere: RCSB PDB 4ZXK · PDBe 4ZXK · UniProt P62575

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