UniProt P62575
Sialidase A (P62575)
Sialidase A (UniProt P62575), EC 3.2.1.18: 12 experimental structures on GenesisL1, 8 ligands bound, 11 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P62575
- Protein
- Sialidase A
- EC
- 3.2.1.18
- Experimental structures
- 12
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 11 · 1 record with a druggable one
Structures
12 records of P62575 in the MolNFT archive: 12 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VVZ | Structure of the catalytic domain of Streptococcus pneumoniae sialidase NanA | x-ray diffraction | A, B | — | — |
| 2VVZ | Structure of the catalytic domain of streptococcus pneumoniae sialidase nana | x-ray diffraction | A, B | — | — |
| 4C1X | Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with… | x-ray diffraction | A | — | — |
| 4C1X | Carbohydrate binding domain from streptococcus pneumoniae nana sialidase complexed with… | x-ray diffraction | A | — | — |
| 4ZXK | Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase | x-ray diffraction | A, B | — | — |
| 4ZXK | Carbohydrate binding domain from streptococcus pneumoniae nana sialidase | x-ray diffraction | A, B | — | — |
| 5KKY | Structure of Streptococcus pneumonia NanA bound with inhibitor 9N3Neu5Ac2en | x-ray diffraction | A, B | 6UD, CL | 11 (best 0.75) |
| 5KKY | Structure of streptococcus pneumonia nana bound with inhibitor 9N3NEU5AC2EN | x-ray diffraction | A, B | 6UD, CL | — |
| 6QZH | Structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric… | x-ray diffraction | A | JLW, NA | — |
| 7A54 | Two copies of the catalytic domain of nana sialidase from streptococcus pneumoniae juxtaposed in… | x-ray diffraction | A, B | DAN | — |
| 7A5X | Two copies of the catalytic domain of nana sialidase from streptococcus pneumoniae juxtaposed in… | x-ray diffraction | A, B | R7H, SO4, CL, CA | — |
| P62575 | AlphaFold monomer V2.0 prediction for sialidase a (P62575) | — | — | — |
Ligands
- CL · Chloride ion · in 3 records
- 6UD · 5-acetamido-2,6-anhydro-3,5,9-trideoxy-9-triazan-1-yl-D-glycero-D-galacto-non-2-enonic acid · in 2 records
- CA · Calcium ion · in 1 record
- DAN · 2-deoxy-2,3-dehydro-N-acetyl-neuraminic acid · in 1 record
- JLW · 3-[[4-[[(1~{R})-2,2-dimethyl-1-(5-methylfuran-2-yl) propyl]amino]-1,1-bis(oxidanylidene)-1,2,5-thiadiazol-3-yl]amino]-~{N},~{N},6-trimethyl-2-oxidanyl-benzamide · in 1 record
- NA · Sodium ion · in 1 record
- R7H · (4~{S},5~{R},6~{R})-5-acetamido-6-[(1~{R},2~{S})-3-[[1-(2-ethoxyethyl)-1,2,3-triazol-4-yl]methylsulfanyl]-1, 2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 6QZH chain A against the predicted model P32248: TM-score 0.36, RMSD 2.07 Å
Elsewhere
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