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Structure of apo human ALDH7A1 in space group P4212

Analyse Structure of apo human ALDH7A1 in space group P4212 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ZVX
Type: protein
Length: 948 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-aminoadipic semialdehyde dehydrogenase
EC: 1.2.1.31, 1.2.1.3, 1.2.1.8
UniProt: P49419
Pockets: 8 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Alpha-aminoadipic semialdehyde dehydrogenase (EC 1.2.1.31, 1.2.1.3, 1.2.1.8)	protein	474	44% helix, 22% strand	P49419

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	545	0.69	0.79	75	empty
2	295	0.53	0.74	39	empty
3	117	0.50	0.80	30	empty
4	190	0.49	0.76	21	empty
5	75	0.49	0.84	21	empty

Interfaces

1 interface between chains.

A–B · 1778 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

4ZVX · Structure of apo human ALDH7A1 in space group P4212 · the same entry in another collection · chain A against A, TM-score 1.00
P49419 · AlphaFold monomer V2.0 prediction for alpha-aminoadipic semialdehyde dehydrogenase… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49419
Elsewhere: RCSB PDB 4ZVX · PDBe 4ZVX · UniProt P49419

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