UniProt P49419
Alpha-aminoadipic semialdehyde dehydrogenase (P49419)
Alpha-aminoadipic semialdehyde dehydrogenase (UniProt P49419), EC 1.2.1.3, 1.2.1.31: 34 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 117 pockets. Binding sites, druggability and experiment against…
- UniProt
- P49419
- Protein
- Alpha-aminoadipic semialdehyde dehydrogenase
- EC
- 1.2.1.3, 1.2.1.31, 1.2.1.8
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 117 · 6 records with a druggable one
Structures
35 records of P49419 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2J6L | Structure of aminoadipate-semialdehyde dehydrogenase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2J6L | Structure of aminoadipate-semialdehyde dehydrogenase | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4X0T | Structure ALDH7A1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+ | x-ray diffraction | A, B, C, D | NAD, 3W9 | 17 (best 0.86) |
| 4X0T | Structure ALDH7A1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+ | x-ray diffraction | A, B, C, D | — | — |
| 4X0U | Structure ALDH7A1 inactivated by 4-diethylaminobenzaldehyde | x-ray diffraction | A, B, C, D | — | — |
| 4ZUK | Structure ALDH7A1 complexed with NAD+ | x-ray diffraction | A, B, C, D, E, F, G, H | NAD | 20 (best 0.87) |
| 4ZUK | Structure ALDH7A1 complexed with NAD+ | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4ZUL | Structure ALDH7A1 complexed with alpha-aminoadipate | x-ray diffraction | A, B, C, D, E, F, G, H | UN1 | 20 (best 0.87) |
| 4ZUL | Structure ALDH7A1 complexed with alpha-aminoadipate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4ZVW | Structure of apo human ALDH7A1 in space group C2 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4ZVX | Structure of apo human ALDH7A1 in space group P4212 | x-ray diffraction | A, B | — | — |
| 4ZVX | Structure of apo human ALDH7A1 in space group P4212 | x-ray diffraction | A, B | — | — |
| 4ZVY | Structure of human ALDH7A1 complexed with NAD+ in space group P4212 | x-ray diffraction | A, B | — | — |
| 4ZVY | Structure of human ALDH7A1 complexed with NAD+ in space group P4212 | x-ray diffraction | A, B | — | — |
| 6O4B | Structure of ALDH7A1 mutant W175G complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, CL | — |
| 6O4B | Structure of ALDH7A1 mutant W175G complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, CL | — |
| 6O4C | Structure of ALDH7A1 mutant W175A complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, CL | — |
| 6O4D | Structure of ALDH7A1 mutant W175A complexed with L-pipecolic acid | x-ray diffraction | A, B, C, D, E, F, G, H | 6PC | — |
| 6O4E | Structure of ALDH7A1 mutant N167S complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD | — |
| 6O4E | Structure of ALDH7A1 mutant N167S complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD | — |
| 6O4F | Structure of ALDH7A1 mutant N167S complexed with alpha-aminoadipate | x-ray diffraction | A, B, C, D, E, F, G, H | UN1 | — |
| 6O4G | Structure of ALDH7A1 mutant P169S complexed with alpha-aminoadipate | x-ray diffraction | A, B, C, D, E, F, G, H | UN1 | 20 (best 0.86) |
| 6O4G | Structure of ALDH7A1 mutant P169S complexed with alpha-aminoadipate | x-ray diffraction | A, B, C, D, E, F, G, H | UN1 | — |
| 6O4H | Structure of ALDH7A1 mutant A171V complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD | — |
| 6O4H | Structure of ALDH7A1 mutant A171V complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD | — |
| 6O4I | Structure of ALDH7A1 mutant E399D complexed with alpha-aminoadipate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6O4I | Structure of ALDH7A1 mutant E399D complexed with alpha-aminoadipate | x-ray diffraction | A, B, C, D, E, F, G, H | UN1 | — |
| 6O4K | Structure of ALDH7A1 mutant E399Q complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, CL | 20 (best 0.86) |
| 6O4K | Structure of ALDH7A1 mutant E399Q complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD, CL | — |
| 6O4L | Structure of ALDH7A1 mutant E399D complexed with NAD | x-ray diffraction | A, B, C, D | CL, NAD | — |
| 6O4L | Structure of ALDH7A1 mutant E399D complexed with NAD | x-ray diffraction | A, B, C, D | CL, NAD | — |
| 6U2X | Structure of ALDH7A1 mutant E399G complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD | 20 (best 0.86) |
| 6U2X | Structure of ALDH7A1 mutant E399G complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD | — |
| 6V0Z | Structure of ALDH7A1 mutant R441C complexed with NAD | x-ray diffraction | A, B, C, D, E, F, G, H | NAD | — |
| P49419 | AlphaFold monomer V2.0 prediction for alpha-aminoadipic semialdehyde dehydrogenase (P49419) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2J6L chain D against the predicted model P49419: TM-score 1.00, RMSD 0.19 Å
- 2J6L chain D against the predicted model P49419: TM-score 1.00, RMSD 0.19 Å
- 2J6L chain E against the predicted model P49419: TM-score 1.00, RMSD 0.20 Å
- 2J6L chain E against the predicted model P49419: TM-score 1.00, RMSD 0.20 Å
- 2J6L chain C against the predicted model P49419: TM-score 1.00, RMSD 0.20 Å
- 2J6L chain C against the predicted model P49419: TM-score 1.00, RMSD 0.20 Å
- 6O4C chain G against the predicted model P49419: TM-score 1.00, RMSD 0.21 Å
- 2J6L chain G against the predicted model P49419: TM-score 1.00, RMSD 0.21 Å
- 2J6L chain G against the predicted model P49419: TM-score 1.00, RMSD 0.21 Å
- 6O4B chain D against the predicted model P49419: TM-score 1.00, RMSD 0.21 Å
Elsewhere
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