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Structure of merlin-ferm and ctd

Analyse Structure of merlin-ferm and ctd in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ZRJ
Type: protein
Length: 379 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Merlin
UniProt: P35240
Pockets: 4 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Merlin	protein	302	37% helix, 24% strand	P35240
B	Merlin	protein	77	82% helix, 1% strand	P35240

Ligands and binding sites

GOL · Glycerol · additive · 8 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	276	0.61	0.79	27	GOL
2	174	0.58	0.82	36	GOL
3	338	0.58	0.76	35	empty
4	69	0.35	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 1996 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

4ZRJ · Structure of Merlin-FERM and CTD · the same entry in another collection · chain A against A, TM-score 1.00
P35240 · AlphaFold monomer V2.0 prediction for merlin (P35240) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

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Every structure of UniProt P35240
Elsewhere: RCSB PDB 4ZRJ · PDBe 4ZRJ · UniProt P35240

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