Research workbench
Hydroxylase domain of SCS7P
Analyse Hydroxylase domain of SCS7P in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZR1
- Type
- protein
- Length
- 549 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ceramide very long chain fatty acid hydroxylase SCS7
- EC
- 1.-.-.-
- UniProt
- Q03529
- Ligands
- TRD, ZN
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ceramide very long chain fatty acid hydroxylase SCS7 (EC 1.-.-.-) | protein | 274 | 58% helix, 1% strand | Q03529 |
| B | Ceramide very long chain fatty acid hydroxylase SCS7 (EC 1.-.-.-) | protein | 275 | 57% helix, 1% strand | Q03529 |
Ligands and binding sites
- TRD · Tridecane · ligand · 8 copies · chains A, B
- ZN · Zinc ion · metal · 4 copies · chains A, B
- BOG · octyl beta-D-glucopyranoside · additive · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 871 | 0.80 | 0.82 | 92 | BOG, TRD |
| 2 | 898 | 0.79 | 0.81 | 56 | BOG, TRD |
| 3 | 165 | 0.67 | 0.86 | 26 | TRD |
| 4 | 118 | 0.53 | 0.82 | 26 | empty |
| 5 | 117 | 0.49 | 0.80 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 476 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03529
- Elsewhere: RCSB PDB 4ZR1 · PDBe 4ZR1 · UniProt Q03529
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