Research workbench
Crystal structure of 2-hydroxybiphenyl 3-monooxygenase from pseudomonas azelaica
Analyse Crystal structure of 2-hydroxybiphenyl 3-monooxygenase from pseudomonas azelaica in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Z2R
- Type
- protein
- Length
- 1,129 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2-hydroxybiphenyl-3-monooxygenase
- UniProt
- O06647
- Ligands
- FAD
- Pockets
- 12 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2-hydroxybiphenyl-3-monooxygenase | protein | 566 | 36% helix, 22% strand | O06647 |
| B | 2-hydroxybiphenyl-3-monooxygenase | protein | 563 | 36% helix, 23% strand | O06647 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1018 | 0.80 | 0.82 | 87 | FAD |
| 2 | 932 | 0.80 | 0.82 | 97 | empty |
| 3 | 964 | 0.79 | 0.81 | 92 | FAD |
| 4 | 191 | 0.53 | 0.78 | 33 | empty |
| 5 | 94 | 0.45 | 0.80 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 464 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 4Z2R · Crystal structure of 2-hydroxybiphenyl 3-monooxygenase from Pseudomonas azelaica · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O06647
- Elsewhere: RCSB PDB 4Z2R · PDBe 4Z2R · UniProt O06647
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