Research workbench
Structure of factor inhibiting hif (fih) in complex with fe, no, and nog
Analyse Structure of factor inhibiting hif (fih) in complex with fe, no, and nog in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Z1V
- Type
- protein
- Length
- 341 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxia-inducible factor 1-alpha inhibitor
- EC
- 1.14.11.30, 1.14.11.-
- UniProt
- Q9NWT6
- Ligands
- OGA, FE, SO4, NO
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30, 1.14.11.-) | protein | 341 | 30% helix, 25% strand | Q9NWT6 |
Ligands and binding sites
- OGA · N-oxalylglycine · ligand · chains A
- FE · Fe (III) ion · metal · chains A
- SO4 · Sulfate ion · ion · 5 copies · chains A
- NO · Nitric oxide · ion · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 384 | 0.63 | 0.78 | 36 | OGA, NO, PEG, FE |
| 2 | 80 | 0.46 | 0.81 | 23 | empty |
| 3 | 134 | 0.41 | 0.75 | 23 | empty |
| 4 | 85 | 0.38 | 0.76 | 21 | empty |
Compared structures
- 4Z1V · Structure of Factor Inhibiting HIF (FIH) in complex with Fe, NO, and NOG · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NWT6 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha inhibitor (Q9NWT6) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWT6
- Elsewhere: RCSB PDB 4Z1V · PDBe 4Z1V · UniProt Q9NWT6
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