Research workbench
Crystal structure of blue-shifted channelrhodopsin mutant (T198G/G202A)
Analyse Crystal structure of blue-shifted channelrhodopsin mutant (T198G/G202A) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YZI
- Type
- protein
- Length
- 289 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensory opsin A,ARCHAEAL-type opsin 2
- UniProt
- Q8L435, Q8RUT8
- Ligands
- OLA, RET, ZN
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 66% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensory opsin A,ARCHAEAL-type opsin 2 | protein | 289 | 66% helix, 6% strand | Q8L435, Q8RUT8 |
Ligands and binding sites
- OLA · Oleic acid · ligand · 5 copies · chains A
- RET · Retinal · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 217 | 0.77 | 0.91 | 31 | RET |
| 2 | 150 | 0.68 | 0.88 | 40 | empty |
| 3 | 135 | 0.53 | 0.81 | 29 | empty |
| 4 | 145 | 0.52 | 0.80 | 21 | empty |
Modifications
Observed in the structure: 1 cofactor (retinal Schiff base).
Compared structures
- 4YZI · Crystal structure of blue-shifted channelrhodopsin mutant (T198G/G202A) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8L435
- Every structure of UniProt Q8RUT8
- Elsewhere: RCSB PDB 4YZI · PDBe 4YZI · UniProt Q8L435 · UniProt Q8RUT8
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