Research workbench
Structure and function of the hypertension variant A486V of G protein- coupled receptor kinase 4 (GRK4)
Analyse Structure and function of the hypertension variant A486V of G protein- coupled… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YHJ
- Type
- protein
- Length
- 991 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G protein-coupled receptor kinase 4
- EC
- 2.7.11.16
- UniProt
- P32298
- Ligands
- AN2
- Pockets
- 16 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G protein-coupled receptor kinase 4 (EC 2.7.11.16) | protein | 501 | 44% helix, 11% strand | P32298 |
| B | G protein-coupled receptor kinase 4 (EC 2.7.11.16) | protein | 490 | 48% helix, 11% strand | P32298 |
Ligands and binding sites
- AN2 · Amp phosphoramidate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 883 | 0.79 | 0.82 | 72 | empty |
| 2 | 194 | 0.79 | 0.94 | 28 | empty |
| 3 | 647 | 0.76 | 0.82 | 77 | AN2 |
| 4 | 383 | 0.71 | 0.83 | 42 | empty |
| 5 | 413 | 0.71 | 0.82 | 50 | AN2 |
Interfaces
1 interface between chains.
- A–B · 2264 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 4YHJ · Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- P32298 · AlphaFold monomer V2.0 prediction for G protein-coupled receptor kinase 4 (P32298) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32298
- Elsewhere: RCSB PDB 4YHJ · PDBe 4YHJ · UniProt P32298
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