Crystal structure of TRIM24 phd-bromodomain complexed with N-{1,3- dimethyl-6-[3-(2-METHYLPROPOXY)PHENOXY]-2-oxo-2,3-dihydro-1H-1,3- benzodiazol-5-yl}-1,2-dimethyl-1H-imidazole-4-sulfonamide (7G)

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 2% strand (DSSP).

Ligands and binding sites

• 4BK · N-{1,3-dimethyl-6-[3-(2-methylpropoxy)phenoxy]-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}-1,2-dimethyl-1H-imidazole-4-sulfonamide · ligand · chains A
• ZN · Zinc ion · metal · 2 copies · chains A
• DMS · Dimethyl sulfoxide · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 4YBS · Crystal structure of TRIM24 PHD-bromodomain complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
• O15164 · AlphaFold monomer V2.0 prediction for transcription intermediary factor 1-alpha (O15164) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O15164
• Elsewhere: RCSB PDB 4YBS · PDBe 4YBS · UniProt O15164