UniProt O15164
Transcription intermediary factor 1-alpha (O15164)
Transcription intermediary factor 1-alpha (UniProt O15164), EC 2.3.2.27, 6.3.2.-: 38 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 20 pockets. Binding sites, druggability and experiment against…
- UniProt
- O15164
- Protein
- Transcription intermediary factor 1-alpha
- EC
- 2.3.2.27, 6.3.2.-
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 20 · 2 records with a druggable one
Structures
39 records of O15164 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YYN | Crystal structure of human bromodomain protein | x-ray diffraction | A, B, C, D | — | — |
| 2YYN | Crystal structure of human bromodomain protein | x-ray diffraction | A, B, C, D | — | — |
| 3O33 | Crystal structure of TRIM24 PHD-Bromo in the free state | x-ray diffraction | A, B, C, D | — | — |
| 3O33 | Crystal structure of TRIM24 phd-bromo in the free state | x-ray diffraction | A, B, C, D | — | — |
| 3O34 | Crystal structure of TRIM24 PHD-Bromo complexed with H3(13-32)K23ac peptide | x-ray diffraction | A | — | — |
| 3O34 | Crystal structure of TRIM24 phd-bromo complexed with H3(13-32)K23AC peptide | x-ray diffraction | A | — | — |
| 3O35 | Crystal structure of TRIM24 PHD-Bromo complexed with H3(23-31)K27ac peptide | x-ray diffraction | A, B | — | — |
| 3O35 | Crystal structure of TRIM24 phd-bromo complexed with H3(23-31)K27AC peptide | x-ray diffraction | A, B | — | — |
| 3O36 | Crystal structure of TRIM24 PHD-Bromo complexed with H4(14-19)K16ac peptide | x-ray diffraction | A, B | — | — |
| 3O36 | Crystal structure of TRIM24 phd-bromo complexed with H4(14-19)K16AC peptide | x-ray diffraction | A, B | — | — |
| 3O37 | Crystal structure of TRIM24 PHD-Bromo complexed with H3(1-10)K4 peptide | x-ray diffraction | A, B, C, D | — | — |
| 3O37 | Crystal structure of TRIM24 phd-bromo complexed with H3(1-10)K4 peptide | x-ray diffraction | A, B, C, D | — | — |
| 4YAB | Crystal structure of TRIM24 PHD-bromodomain complexed with 1-methyl-5-(2-methyl-1 3-thiazol-4-yl)-2… | x-ray diffraction | A, B | ZN, 4CN, SO4 | 4 (best 0.44) |
| 4YAB | Crystal structure of TRIM24 phd-bromodomain complexed with 1-methyl-5- (2-methyl-1… | x-ray diffraction | A, B | — | — |
| 4YAD | Crystal structure of TRIM24 PHD-bromodomain complexed with… | x-ray diffraction | A, B | — | — |
| 4YAD | Crystal structure of TRIM24 phd-bromodomain complexed with 2,4… | x-ray diffraction | A, B | — | — |
| 4YAT | Crystal structure of TRIM24 PHD-bromodomain complexed with… | x-ray diffraction | A, B | — | — |
| 4YAT | Crystal structure of TRIM24 phd-bromodomain complexed with N-(1,3… | x-ray diffraction | A, B | — | — |
| 4YAX | Crystal structure of TRIM24 PHD-bromodomain complexed with… | x-ray diffraction | A, B | — | — |
| 4YAX | Crystal structure of TRIM24 phd-bromodomain complexed with N-[6-(4… | x-ray diffraction | A, B | — | — |
| 4YBM | Crystal structure of TRIM24 PHD-bromodomain complexed with… | x-ray diffraction | A, B | — | — |
| 4YBM | Crystal structure of TRIM24 phd-bromodomain complexed with N-{6-[3… | x-ray diffraction | A, B | — | — |
| 4YBS | Crystal structure of TRIM24 PHD-bromodomain complexed with… | x-ray diffraction | A | — | — |
| 4YBS | Crystal structure of TRIM24 phd-bromodomain complexed with N-{1,3… | x-ray diffraction | A | — | — |
| 4YBT | Crystal structure of TRIM24 PHD-bromodomain complexed with… | x-ray diffraction | A | — | — |
| 4YBT | Crystal structure of TRIM24 phd-bromodomain complexed with N-{1,3… | x-ray diffraction | A | — | — |
| 4YC9 | Crystal structure of TRIM24 PHD-bromodomain complexed with… | x-ray diffraction | A | — | — |
| 4YC9 | Crystal structure of TRIM24 phd-bromodomain complexed with N-(6-{3-[4… | x-ray diffraction | A | — | — |
| 4ZQL | Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydr… | x-ray diffraction | A, B | — | — |
| 4ZQL | Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4… | x-ray diffraction | A, B | — | — |
| 5H1T | Complex structure of TRIM24 PHD-bromodomain and inhibitor 1 | x-ray diffraction | A, B, C, D | ZN, 7FF | 9 (best 0.62) |
| 5H1T | Complex structure of TRIM24 phd-bromodomain and inhibitor 1 | x-ray diffraction | A, B, C, D | — | — |
| 5H1U | Complex structure of TRIM24 PHD-bromodomain and inhibitor 2 | x-ray diffraction | B, A, C, D | 6KT, ZN | — |
| 5H1U | Complex structure of TRIM24 phd-bromodomain and inhibitor 2 | x-ray diffraction | B, A, C, D | — | — |
| 5H1V | Complex structure of TRIM24 PHD-bromodomain and inhibitor 6 | x-ray diffraction | A, B | ZN, 7FU | — |
| 5H1V | Complex structure of TRIM24 phd-bromodomain and inhibitor 6 | x-ray diffraction | A, B | — | — |
| 7B9X | NMR2 structure of TRIM24-BD in complex with a precursor of IACS-9571 | solution nmr | A | T52 | 1 (best 0.50) |
| 7B9X | NMR2 structure of TRIM24-bd in complex with a precursor of iacs-9571 | solution nmr | A | T52 | — |
| O15164 | AlphaFold monomer V2.0 prediction for transcription intermediary factor 1-alpha (O15164) | predicted | A | — | 6 (best 0.41) |
Ligands
- ZN · Zinc ion · in 4 records
- T52 · N-{6-[3-(4-Aminobutoxy)-5-propoxyphenoxy]-1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl}-3,4-dimethoxybenzene-1-sulfonamide · in 2 records
- 4CN · 1-methyl-5-(2-methyl-1,3-thiazol-4-yl)-1,3-dihydro-2H-indol-2-one · in 1 record
- 6KT · 2-amino-1,3-benzothiazole-6-carboxamide · in 1 record
- 7FF · methyl 6-azanyl-3,4-dihydro-2H-quinoline-1-carboxylate · in 1 record
- 7FU · 2-Hydrazino-1,3-benzothiazole-6-carbohydrazide · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 2YYN chain A against the predicted model O15164: TM-score 0.98, RMSD 0.63 Å
- 2YYN chain A against the predicted model O15164: TM-score 0.98, RMSD 0.63 Å
- 2YYN chain B against the predicted model O15164: TM-score 0.98, RMSD 0.64 Å
- 2YYN chain B against the predicted model O15164: TM-score 0.98, RMSD 0.64 Å
- 4YAT chain B against the predicted model O15164: TM-score 0.98, RMSD 1.05 Å
- 4YAT chain B against the predicted model O15164: TM-score 0.98, RMSD 1.05 Å
- 4ZQL chain B against the predicted model O15164: TM-score 0.98, RMSD 1.11 Å
- 4ZQL chain B against the predicted model O15164: TM-score 0.98, RMSD 1.11 Å
- 5H1U chain B against the predicted model O15164: TM-score 0.97, RMSD 1.15 Å
- 5H1U chain B against the predicted model O15164: TM-score 0.97, RMSD 1.15 Å
Elsewhere
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