Crystal structure of TRIM24 phd-bromodomain complexed with 2,4- dimethoxy-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-YL)BENZENE- 1-sulfonamide (3B)

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 2% strand (DSSP).

Ligands and binding sites

• 4A7 · 2,4-dimethoxy-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)benzenesulfonamide · ligand · 2 copies · chains A, B
• ZN · Zinc ion · metal · 4 copies · chains A, B
• CL · Chloride ion · ion · 2 copies · chains A, B
• GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 128 Ų buried · 3 hydrogen bonds · protein-protein

Compared structures

• 4YAD · Crystal structure of TRIM24 PHD-bromodomain complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
• O15164 · AlphaFold monomer V2.0 prediction for transcription intermediary factor 1-alpha (O15164) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O15164
• Elsewhere: RCSB PDB 4YAD · PDBe 4YAD · UniProt O15164