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Crystal structure of WDR5 in complex with myc mbiiib peptide

Analyse Crystal structure of WDR5 in complex with myc mbiiib peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4Y7R
Type: protein
Length: 312 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wd repeat-containing protein 5; Myc mbiiib peptide
UniProt: P61964
Pockets: 1 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wd repeat-containing protein 5	protein	304	0% helix, 50% strand	P61964
B	Myc mbiiib peptide	protein	8	0% helix, 0% strand	—

Ligands and binding sites

TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	691	0.77	0.82	63	TRS

Interfaces

1 interface between chains.

A–B · 453 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4Y7R · Crystal structure of WDR5 in complex with MYC MbIIIb peptide · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61964
Elsewhere: RCSB PDB 4Y7R · PDBe 4Y7R · UniProt P61964

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