Research workbench
Human CTP: phosphoethanolamine cytidylyltransferase in complex with CTP
Analyse Human CTP: phosphoethanolamine cytidylyltransferase in complex with CTP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XSV
- Type
- protein
- Length
- 306 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ethanolamine-phosphate cytidylyltransferase
- EC
- 2.7.7.14
- UniProt
- Q99447
- Ligands
- C5P, CTP
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) | protein | 306 | 35% helix, 18% strand | Q99447 |
Ligands and binding sites
- C5P · Cytidine-5'-monophosphate · ligand · chains A
- CTP · Cytidine-5'-triphosphate · ligand · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.76 | 0.87 | 36 | C5P |
| 2 | 459 | 0.65 | 0.78 | 41 | CTP |
Compared structures
- 4XSV · Human CTP: Phosphoethanolamine Cytidylyltransferase in complex with CTP · the same entry in another collection · chain A against A, TM-score 1.00
- Q99447 · AlphaFold monomer V2.0 prediction for ethanolamine-phosphate cytidylyltransferase (Q99447) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99447
- Elsewhere: RCSB PDB 4XSV · PDBe 4XSV · UniProt Q99447
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