Research workbench
Structure of the saccharomyces cerevisiae PAN2-PAN3 core complex
Analyse Structure of the saccharomyces cerevisiae PAN2-PAN3 core complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XR7
- Type
- protein
- Length
- 6,206 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pab-dependent POLY(A)-specific ribonuclease subunit PAN2; Pab-dependent POLY(A)-specific…
- EC
- 3.1.13.4
- UniProt
- P53010, P36102
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 12 distinct chains · 37% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Pab-dependent POLY(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) | protein | 683 | 26% helix, 22% strand | P53010 |
| L | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 441 | 46% helix, 13% strand | P36102 |
| K | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 431 | 45% helix, 14% strand | P36102 |
| E | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 414 | 46% helix, 14% strand | P36102 |
| F | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 442 | 46% helix, 12% strand | P36102 |
| D | Pab-dependent POLY(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) | protein | 683 | 27% helix, 21% strand | P53010 |
| H | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 420 | 45% helix, 14% strand | P36102 |
| I | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 437 | 45% helix, 13% strand | P36102 |
| J | Pab-dependent POLY(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) | protein | 681 | 27% helix, 21% strand | P53010 |
| C | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 444 | 46% helix, 14% strand | P36102 |
| B | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 429 | 44% helix, 14% strand | P36102 |
| A | Pab-dependent POLY(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) | protein | 701 | 27% helix, 22% strand | P53010 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1083 | 0.84 | 0.85 | 96 | empty |
| 2 | 1170 | 0.83 | 0.84 | 106 | empty |
| 3 | 1056 | 0.82 | 0.83 | 108 | empty |
| 4 | 871 | 0.82 | 0.84 | 108 | empty |
| 5 | 815 | 0.80 | 0.83 | 67 | empty |
Interfaces
23 interfaces between chains.
- C–B · 4411 Ų buried · 42 hydrogen bonds · protein-protein
- L–K · 4314 Ų buried · 47 hydrogen bonds · protein-protein
- H–I · 3997 Ų buried · 40 hydrogen bonds · protein-protein
- E–F · 3944 Ų buried · 43 hydrogen bonds · protein-protein
- B–A · 2774 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 4XR7 · Structure of the Saccharomyces cerevisiae PAN2-PAN3 core complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53010
- Every structure of UniProt P36102
- Elsewhere: RCSB PDB 4XR7 · PDBe 4XR7 · UniProt P53010 · UniProt P36102
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